结直肠癌干细胞表面标志物和信号通路研究进展 B

既往临床实验证实棉酚可以用 来治疗前列腺癌等多种肿瘤，通过SRP和NMR实 验发现，棉酚( gossypol)可与Msil RBD1相结合，与 Bcl-2家族的结合相比有着更高的亲和力，增加了Numb和APC的表达，抑制Wnt和Notch通路，起到治疗结直肠癌的作用[17]。沉默Msil的结直肠癌细胞克隆形成能力下降、肿瘤生长速度减慢、细胞周期停滞在G7/M期，给予沉默Msil的结肠癌HCT116细胞12 Gy放射线照射，细胞凋亡数增加了4倍，表明沉默Msil能使放疗敏感性增加，另有研究证实β -catenin对于放疗具有抗性，而Msil可 能通过促进B -catenin的核内聚，增加了结直肠癌放疗的不敏感性[19]。

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