促代谢因子betatrophin与糖尿病的研究进展
文章来源：基础医学与临床发布日期：2017-05-28浏览次数：162 5展望糖尿病患者与非糖尿病患者相比，糖类脂类代谢异常的风险性增加大约3倍，且糖尿病患者发生 糖类脂类异常的年龄更早，大血管病变等并发症病灶更严重、更广泛，预后也更差[24]。Betatrophin可以促进胰岛β细胞的增殖，结合作者前期研究结果，2型糖尿病（type 2 diabetes mellitus，T2DM）大血管病变组血清betatrophin水平高于新诊断T2DM组，且新诊断T2DM组血清betatrophin水平高于健康对照组。说明血清betatrophin水平与T2DM大血管病变发生发展存在某种关联，但具体的影响机制并不清楚，下一步研究针对血清betatrophin水平与T2DM大血管病变相关因子的关系，给予2型糖尿病及2型糖尿病大血管病变提供新的理论依据和临床指导，将有助于更进一步了解糖尿病以及糖尿病大血管病变等并发症的机制与治疗，更大程度地降低糖尿病及糖尿病大血管病变等并发症的危害。 参考文献 [1] Ouaamari EA, Kawamori D, Dirice E, et al. Liver-derived systemic factors drive beta cell hyperplasia in insulin-resistant states [J] . Cell Rep, 2013 ,3 :401-410.[2] Ungefroren H, Hyder A, Schulze M, et al. Peripheral blood monocytes as adult stem cells: molecular characterization and improvements in culture conditions to enhance stem cell features and proliferative potential[ J] . Stem Cells Int, 2016 ,2016 :7132751. doi: 10. 1155/2016/7132751.[3] Yi P, Park JS, Melton DA. Betatrophin: a hormone that controls pancreatic β cell proliferation [J]. Cell, 2013,153 :747-758.[4] Abu-Farha M, Sriraman D, Cherian P, et al. Circulating ANGPTL8/Betatrophin is increased in obesity and reduced after exercise training [ J ] . PLoS One , 2016 ,11 : e0147367.doi: 10. 1371/journal. pone. 0147367.[5] Chen CC, Susanto H, Chuang WH, et al. Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function[ J] . Cardiovase Diabetol, 2016,15:3. doi: 10. 1186/s12933-015-0326- 9.[6] Arias-Loste MT, Llerena S, Iruzubieta P, et a/. Plasma betatrophin levels in patients with liver cirrhosis[ J] . World J Diabetes, 2015 ,21:10662-10668.[7] Tang T, Li L, Tang J, et al. A mouse knockout library for secrete and transmembrane proteins [J]. Nat Biotechnol,2010,28:749-755.[8] Ren G, Kim JY, Smas CM. Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid me[x]tabolism[J]. Am J Physiol Endocrinol me[x]tab, 2012,303 :e334- e351.[9] Zhang R. Lipasin, a novel nutritionally-regulated liver-en-riched factor that regulates serum triglyceride levels [ J].Biochem Biophys Res Commun, 2012,424:786-792.[ 10] Quagliarini F, Wang Y, Kozlitina J, et al. Atypical angiopoietin-like protein that regulates ANGPTL3 [ J]. Proc Natl Acad Sci U S A, 2012,109:19751-19756.[11] Abu FM, Abubaker J, Al KI, et al Higher plasma betatrophin/ANGPTL8 level in type 2 diabetes subjects does not correlate with blood glucose or insulin resistance [ J] .Sci Rep, 2015,5 :10949. doi: 10. 1038/srep10949. 
